Treatment of chronic generalized periodontitis in patients with underlying hypovitaminosis D: randomized comparative clinical trial

Objectives This study aims to evaluate the dynamics of clinical and laboratory indicators periodontal state hemodynamics in patients receiving pharmaceutical intervention for treatment vitamin D deficiency as a part complex therapy chronic generalized periodontitis. Methodology was randomized prospective comparative trial. It involved 110 with moderate periodontitis (25(OH)<50 nmol/L) who were divided into two experimental groups. One group received conventional treatment, whereas other deficiency(vitamin D3 + calcium). Results A significant reduction inflammation observed across all groups starting from day 14 treatment. However, longer perspective (12 18 months after treatment), indices analyzed remained fairly stable corresponded stabilization stage both The demonstrated marked tendency return baseline. Conclusions Pharmacotherapy contributed normalization microcirculation (the σ Kv values approached those healthy periodontium) evidenced by immediate long-term follow-up results. Clinical observation suffering underlying hypovitaminosis makes an argument use supplementation correction Trial registration number: NCT67823273